Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance.

Molecular microbiology - 1 May 2004

Hong Hee-Jeon, Hutchings Matthew I, Neu John M, Wright Gerard D, Paget Mark S B, Buttner Mark J

Abstract excerpt

Vancomycin is the front-line therapy for treating problematic infections caused by methicillin-resistant Staphylococcus aureus (MRSA), and the spread of vancomycin resistance is an acute problem. Vancomycin blocks cross-linking between peptidoglycan intermediates by binding to the D-Ala-D-Ala termini of bacterial cell wall precursors, which are the substrate of transglycosylase/transpeptidase. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carbon-Oxygen Ligases
Share to Gene Order

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Kanamycin Resistance

Share to Operon

Share to Streptomyces

Share to Teicoplanin

Share to Vancomycin

Share to Vancomycin Resistance

Source

Identifiers

PMID: 15130128
DOI: 10.1111/j.1365-2958.2004.04032.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance.PMID 15130128Read ↗

The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor.Semantic proximity Read ↗

A novel membrane protein, VanJ, conferring resistance to teicoplanin.Semantic proximity Read ↗

The vancomycin resistance VanRS two-component signal transduction system of Streptomyces coelicolor.Semantic proximity Read ↗

Understanding the genome-wide response of Streptomyces coelicolor to the glycopeptide antibiotic teicoplaninSemantic proximity Read ↗

Transcriptional response to vancomycin in a highly vancomycin-resistant Streptomyces coelicolor mutant.Semantic proximity Read ↗

Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component SystemSemantic proximity Read ↗

Molecular Events for Promotion of Vancomycin Resistance in Vancomycin Intermediate Staphylococcus aureusSemantic proximity Read ↗

Vancomycin-Variable Enterococci Can Give Rise to Constitutive Resistance during Antibiotic TherapySemantic proximity Read ↗

walK and clpP mutations confer reduced vancomycin susceptibility in Staphylococcus aureus.Semantic proximity Read ↗

VraT/YvqF Is Required for Methicillin Resistance and Activation of the VraSR Regulon in Staphylococcus aureusSemantic proximity Read ↗

The VanS sensor histidine kinase from type-B VRE recognizes vancomycin directlySemantic proximity Read ↗

The escalating challenge of vancomycin resistance in Staphylococcus aureus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.