Article

Understanding the genome-wide response of Streptomyces coelicolor to the glycopeptide antibiotic teicoplanin

2021-01-01

Abstract excerpt

The glycopeptide antibiotics vancomycin and teicoplanin are clinically important as a second-line therapy to treat nosocomial infections caused by Gram-positive pathogens. Glycopeptide antibiotics universally target the terminal residues, D-Alanyl-D-Alanine on the cell wall peptidoglycan intermediate lipid II, interfering with peptidoglycan biosynthesis and weakening the cell wall. A general resistance mechanism t...

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Literature Corpus work: 7a4d5bab-3f8f-5221-a5ad-929c98eea17a
DOI: 10.24384/14qa-m159

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