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Article

Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.

Antimicrobial agents and chemotherapy - 1 Jun 2010

Marcone Giorgia Letizia, Beltrametti Fabrizio, Binda Elisa, Carrano Lucia, Foulston Lucy, Hesketh Andrew, Bibb Mervyn, Marinelli Flavia

Abstract excerpt

In glycopeptide-resistant enterococci and staphylococci, high-level resistance is achieved by replacing the C-terminal d-alanyl-d-alanine of lipid II with d-alanyl-d-lactate, thus reducing glycopeptide affinity for cell wall targets. Reorganization of the cell wall in these organisms is directed by the vanHAX gene cluster. Similar self-resistance mechanisms have been reported for glycopeptide-producing...

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Identifiers

PMID: 20308385
DOI: 10.1128/AAC.00106-10
PMCID: PMC2876364

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.PMID 20308385Read ↗

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