Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor.

The Journal of biological chemistry - 1 Apr 2005

Hong Hee-Jeon, Hutchings Matthew I, Hill Lionel M, Buttner Mark J

Abstract excerpt

The non-pathogenic, non-glycopeptide-producing actinomycete Streptomyces coelicolor carries a cluster of seven genes (vanSRJKHAX) that confers inducible, high level resistance to vancomycin. The vanK gene has no counterpart in previously characterized vancomycin resistance clusters, yet vanK is required for vancomycin resistance in S. coelicolor. VanK belongs to the Fem family of enzymes, which add the branch...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatography, Liquid
Share to Lactates
Share to Models, Chemical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotides

Share to Peptidoglycan

Share to Spectrometry, Mass, Electrospray Ionization

Share to Streptomyces coelicolor

Share to Vancomycin

Source

Identifiers

PMID: 15632111
DOI: 10.1074/jbc.M413801200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of the novel Fem protein VanK in vancomycin resistance in Streptomyces coelicolor.PMID 15632111Read ↗

Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance.Semantic proximity Read ↗

A novel membrane protein, VanJ, conferring resistance to teicoplanin.Semantic proximity Read ↗

The vancomycin resistance VanRS two-component signal transduction system of Streptomyces coelicolor.Semantic proximity Read ↗

Understanding the genome-wide response of Streptomyces coelicolor to the glycopeptide antibiotic teicoplaninSemantic proximity Read ↗

Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component SystemSemantic proximity Read ↗

Transcriptional response to vancomycin in a highly vancomycin-resistant Streptomyces coelicolor mutant.Semantic proximity Read ↗

VanZ Reduces the Binding of Lipoglycopeptide Antibiotics to Staphylococcus aureus and Streptococcus pneumoniae CellsSemantic proximity Read ↗

MurAA is required for intrinsic cephalosporin resistance of Enterococcus faecalis.Semantic proximity Read ↗

VraT/YvqF Is Required for Methicillin Resistance and Activation of the VraSR Regulon in Staphylococcus aureusSemantic proximity Read ↗

Resistance to Glycopeptide Antibiotics in the Teicoplanin Producer Is Mediated by <i>van</i> Gene Homologue Expression Directing the Synthesis of a Modified Cell Wall PeptidoglycanSemantic proximity Read ↗

VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405.Semantic proximity Read ↗

Genome sequencing analysis of Streptomyces coelicolor mutants that overcome the phosphate-depending vancomycin lethal effect.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.