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Article

Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and beta-catenin mutated hepatomas.

Drug metabolism and disposition: the biological fate of chemicals - 1 Apr 2007

Braeuning Albert, Ittrich Carina, Köhle Christoph, Buchmann Albrecht, Schwarz Michael

Abstract excerpt

Hepatocytes of the periportal and perivenous zones of the liver lobule differ in their levels and activities of various enzymes and other proteins. We have recently suggested that beta-catenin- and Ras-dependent signaling pathways play an important role in the regulation of perivenous and periportal gene expression profiles. This hypothesis was primarily based on similarities in zonal differences in gene...

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Identifiers

PMID: 17220236
DOI: 10.1124/dmd.106.013656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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