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Article

Phenotype and growth behavior of residual β-catenin-positive hepatocytes in livers of β-catenin-deficient mice.

Histochemistry and cell biology - 1 Nov 2010

Braeuning Albert, Singh Yasmin, Rignall Benjamin, Buchmann Albrecht, Hammad Seddik, Othman Amnah, von Recklinghausen Iris, Godoy Patricio, Hoehme Stefan, Drasdo Dirk, Hengstler Jan G, Schwarz Michael

Abstract excerpt

Signaling through the Wnt/β-catenin pathway is a crucial determinant of hepatic zonal gene expression, liver development, regeneration, and tumorigenesis. Transgenic mice with hepatocyte-specific knockout of Ctnnb1 (encoding β-catenin) have proven their usefulness in elucidating these processes. We now found that a small number of hepatocytes escape the Cre-mediated gene knockout in that mouse model. The...

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PMID: 20886225
DOI: 10.1007/s00418-010-0747-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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