Article
Overview of the molecular biology of hepatocellular neoplasms and hepatoblastomas of the mouse liver.
Toxicologic pathology - 1 Jan 2005
Kim Yongbaek, Sills Robert C, Houle Chris D
Abstract excerpt
The molecular pathogenesis of chemically induced hepatocellular neoplasms and hepatoblastomas in the B6C3FI mouse is unclear but may involve alterations in the fi-catenin/Wnt signaling pathway as was recently described for human liver neoplasms. The objectives of this research were to characterize the mutation frequency and spectrum of P-catenin mutations and the intracellular localization of I-catenin protein...
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