Article
Heterogeneous phenotypes of Pten-null hepatocellular carcinoma in hepatitis B virus transgenic mice parallels liver lobule zonal gene expression patterns.
Virology - 1 Jan 2022
Oropeza Claudia E, Ondracek Caitlin R, Tarnow Grant, Maienschein-Cline Mark, Green Stefan J, McLachlan Alan
Abstract excerpt
Chronic HBV infection is a major cause of hepatocellular carcinoma (HCC) worldwide. The phenotypes of HCC are diverse, in part, due to mutations in distinct oncogenes and/or tumor suppressor genes. These genetic drivers of HCC development have generally been considered as major mediators of tumor heterogeneity. Using the liver-specific Pten-null HBV transgenic mouse model of chronic viral infection, a critical...
Topics
- Animals
- Carcinoma, Hepatocellular
- Cell Transformation, Neoplastic
- Female
- Gene Expression Regulation, Neoplastic
- Genetic Heterogeneity
- Hepatitis B
- Hepatitis B virus
- Hepatocytes
- Hepcidins