Article
Ha-ras and β-catenin oncoproteins orchestrate metabolic programs in mouse liver tumors.
International journal of cancer - 1 Oct 2014
Unterberger Elif B, Eichner Johannes, Wrzodek Clemens, Lempiäinen Harri, Luisier Raphaëlle, Terranova Rémi, Metzger Ute, Plummer Simon, Knorpp Thomas, Braeuning Albert, Moggs Jonathan, Templin Markus F, Honndorf Valerie, Piotto Martial, Zell Andreas, Schwarz Michael
Abstract excerpt
The process of hepatocarcinogenesis in the diethylnitrosamine (DEN) initiation/phenobarbital (PB) promotion mouse model involves the selective clonal outgrowth of cells harboring oncogene mutations in Ctnnb1, while spontaneous or DEN-only-induced tumors are often Ha-ras- or B-raf-mutated. The molecular mechanisms and pathways underlying these different tumor sub-types are not well characterized. Their...
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