Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative transcriptome and proteome analysis of Ha-ras and B-raf mutated mouse liver tumors.

Journal of proteome research - 1 Aug 2009

Rignall Benjamin, Ittrich Carina, Krause Eberhard, Appel Klaus E, Buchmann Albrecht, Schwarz Michael

Abstract excerpt

Mouse liver tumors frequently harbor activating mutations in the Ha-ras protooncogene. In addition, mutations are also found in the B-raf gene leading to constitutive activation of the B-Raf kinase. In two previous studies, we have investigated by microarray analysis the effect of the mutations on the mRNA expression patterns of the respective tumors. In the present study, we analyzed proteome changes in Ha-ras...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comparative Genomic Hybridization
Share to Electrophoresis, Gel, Two-Dimensional

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Linear Models

Share to Liver Neoplasms, Experimental

Share to Mice, Inbred C3H

Share to Proteomics

Share to Proto-Oncogene Proteins B-raf

Share to ras Proteins

Source

Identifiers

PMID: 19476384
DOI: 10.1021/pr9002933

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative transcriptome and proteome analysis of Ha-ras and B-raf mutated mouse liver tumors.PMID 19476384Read ↗

Global gene expression in Ha-ras and B-raf mutated mouse liver tumors.Semantic proximity Read ↗

Proteome analysis of chemically induced mouse liver tumors with different genotype.Semantic proximity Read ↗

Extracellular Matrix Dynamics in Hepatocarcinogenesis: a Comparative Proteomics Study of PDGFC Transgenic and Pten Null Mouse ModelsSemantic proximity Read ↗

Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases.Semantic proximity Read ↗

Gene expression profiling of tumours derived from rasV12/E1A-transformed mouse embryonic fibroblasts to identify genes required for tumour development.Semantic proximity Read ↗

Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation.Semantic proximity Read ↗

Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by ras(V12 )mutated protein and the E1A oncogeneSemantic proximity Read ↗

Proteomics: techniques and applications in cancer research.Semantic proximity Read ↗

p21Ras downstream effectors are increased in activity or expression in mouse liver tumors but do not differ between ras-mutated and ras-wild-type lesions.Semantic proximity Read ↗

Phosphoproteomics Identifies Oncogenic Ras Signaling Targets and Their Involvement in Lung AdenocarcinomasSemantic proximity Read ↗

Zonal gene expression in mouse liver resembles expression patterns of Ha-ras and beta-catenin mutated hepatomas.Semantic proximity Read ↗

Plasma Proteome Profiling of a Mouse Model of Breast Cancer Identifies a Set of Up-Regulated Proteins in Common with Human Breast Cancer CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.