Article
Global gene expression in Ha-ras and B-raf mutated mouse liver tumors.
International journal of cancer - 15 Sept 2007
Jaworski Maike, Ittrich Carina, Hailfinger Stephan, Bonin Michael, Buchmann Albrecht, Schwarz Michael, Köhle Christoph
Abstract excerpt
Chemically-induced mouse liver tumors harbor mutations in different oncogenes. About 50% of tumors contain activating mutations in the Ha-ras gene contain and about 20% of tumors show point mutations in the B-raf oncogene. We have investigated the gene expression profiles in tumors of the 2 genotypes by microarray analysis. In total, approximately 500 genes or expressed sequences were aberrantly expressed in...
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