Article
Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor-like genes.
Molecular and cellular biology - 1 Feb 1999
Bertram M J, Bérubé N G, Hang-Swanson X, Ran Q, Leung J K, Bryce S, Spurgers K, Bick R J, Baldini A, Ning Y, Clark L J, Parkinson E K, Barrett J C, Smith J R, Pereira-Smith O M
Abstract excerpt
Based on the dominance of cellular senescence over immortality, immortal human cell lines have been assigned to four complementation groups for indefinite division. Human chromosomes carrying senescence genes have been identified, including chromosome 4. We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to...
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