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Article

Mechanisms responsible for the limited lifespan and immortal phenotypes in cultured mammalian cells.

Journal of theoretical biology - 7 Feb 1991

Rosenberger R F, Gounaris E, Kolettas E

Abstract excerpt

Normal mammalian cells have a limited lifespan in culture and hypotheses explaining cellular senescence usually fall into one of two categories. One of these postulates that random errors or damage accumulate in essential macromolecules and eventually outstrip the cell's capacity for resynthesis and repair. The second considers the changes when immortal clones are produced from normal cells and in particular the...

Topics

Animals
Cell Survival
Cells, Cultured
Mammals
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2016899
DOI: 10.1016/s0022-5193(05)80243-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2016899-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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