Escape from senescence in hybrid cell clones involves deletions of two regions located on human chromosome 1q.

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Article

Escape from senescence in hybrid cell clones involves deletions of two regions located on human chromosome 1q.

Cancer research - 15 Jan 1996

Karlsson C, Stenman G, Vojta P J, Bongcam-Rudloff E, Barrett J C, Westermark B, Paulsson Y

Abstract excerpt

Human normal cells have been shown to undergo a limited number of cell doublings, a phenomenon termed cellular senescence. Human chromosome 1 has been implicated in this process, and several lines of evidence indicate that there is a senescence-inducing gene or genes on human chromosome 1q. Our a...

Topics

Animals
Base Sequence
Cell Fusion
Cellular Senescence
Chromosome Mapping
Chromosomes, Human, Pair 1
Clone Cells
Cricetinae
Gene Deletion
Humans
Hybrid Cells
Mesocricetus
Mice
Molecular Sequence Data
Mutagenesis, Insertional
Phenotype

Source

Open in PubMed

Identifiers

PMID: 8542573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8542573-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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