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Escape from senescence in hybrid cell clones involves deletions of two regions located on human chromosome 1q.

Cancer research - 15 Jan 1996

Karlsson C, Stenman G, Vojta P J, Bongcam-Rudloff E, Barrett J C, Westermark B, Paulsson Y

Abstract excerpt

Human normal cells have been shown to undergo a limited number of cell doublings, a phenomenon termed cellular senescence. Human chromosome 1 has been implicated in this process, and several lines of evidence indicate that there is a senescence-inducing gene or genes on human chromosome 1q. Our approach to analyze the senescence-inducing effect of chromosome 1 includes the use of somatic cell hybrid revertants....

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PMID: 8542573

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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