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Article

Heparan sulfate binding can contribute to the neurovirulence of neuroadapted and nonneuroadapted Sindbis viruses.

Journal of virology - 1 Apr 2007

Ryman Kate D, Gardner Christina L, Burke Crystal W, Meier Kathryn C, Thompson Joseph M, Klimstra William B

Abstract excerpt

Cell culture-adapted laboratory strains of Sindbis virus (SB) exhibit efficient initial attachment to cell surface heparan sulfate (HS) receptors. In contrast, non-cell-adapted strains, such as the SB consensus sequence virus TR339, interact weakly with HS and cell surfaces. Regardless of their HS binding phenotype, most SB strains do not cause fatal disease in adult mice, whether inoculated subcutaneously (s.c.)...

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Identifiers

PMID: 17215278
DOI: 10.1128/JVI.02494-06
PMCID: PMC1866052

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Source receipt: pubmed, retrieved 7 Sept 2026.

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