Article

Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive EV-A71 virulence in mice

2019-05-23

Abstract excerpt

Enterovirus A71 (EV-A71) causes hand, foot and mouth disease epidemics with neurological complications and fatalities. However, the neuropathogenesis of EV-A71 remains poorly understood. In mice, adaptation and virulence determinants have been mapped to mutations at VP1-145, VP1-244 and VP2-149. We hypothesized that heparin-binding phenotype shapes EV-A71 virulence in mice. We constructed six viruses with varying...

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Literature Corpus work: 724617b1-3e6a-53f7-ac6c-49b1def2c9ec
DOI: 10.1101/648253

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