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Article

Viral determinants of age-dependent virulence of Sindbis virus for mice

1 Aug 1993

Abstract excerpt

Many alphaviruses cause more severe disease in young animals than in older animals. The age-dependent resistance to severe disease is determined primarily by maturation of the host, but strains of virus can be selected that overcome the increased resistance of mature animals. Sindbis virus (SV) strain AR339 causes fatal encephalitis in newborn mice and nonfatal encephalitis in weanling mice, whereas NSV, a...

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PMID: 8392602
DOI: 10.1128/jvi.67.8.4605-4610.1993

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