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Article

Heparan sulfate binding by natural eastern equine encephalitis viruses promotes neurovirulence.

Proceedings of the National Academy of Sciences of the United States of America - 20 Sept 2011

Gardner Christina L, Ebel Gregory D, Ryman Kate D, Klimstra William B

Abstract excerpt

The Alphavirus genus of the family Togaviridae contains mosquito-vectored viruses that primarily cause either arthritogenic disease or acute encephalitis. North American eastern equine encephalitis virus (NA-EEEV) is uniquely neurovirulent among encephalitic alphaviruses, causing mortality in a majority of symptomatic cases and neurological sequelae in many survivors. Unlike many alphaviruses, NA-EEEV infection...

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Identifiers

PMID: 21896745
DOI: 10.1073/pnas.1110617108
PMCID: PMC3179095

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