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Article

Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus.

PloS one - 11 Mar 2010

Zhu Wuyang, Wang Lihua, Yang Yiliang, Jia Juan, Fu Shihong, Feng Yun, He Ying, Li Jin-Ping, Liang Guodong

Abstract excerpt

Cell culture-adapted strains of Sindbis virus (SINV) initially attach to cells by the ability to interact with heparan sulfate (HS) through selective mutation for positively charged amino acid (aa) scattered in E2 glycoprotein (W. B. Klimstra, K. D. Ryman, and R. E. Johnston, J. Virol. 72: 7357-7366, 1998). Here we have further confirmed that interaction of E2 protein with HS is crucial for cellular infection of...

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Identifiers

PMID: 20300181
DOI: 10.1371/journal.pone.0009656
PMCID: PMC2836379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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