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Article

A single mutation in the E2 glycoprotein important for neurovirulence influences binding of sindbis virus to neuroblastoma cells.

Journal of virology - 1 Jun 2002

Lee Peiyu, Knight Ronald, Smit Jolanda M, Wilschut Jan, Griffin Diane E

Abstract excerpt

The amino acid at position 55 of the E2 glycoprotein (E2(55)) of Sindbis virus (SV) is a critical determinant of SV neurovirulence in mice. Recombinant virus strain TE (E2(55) = histidine) differs only at this position from virus strain 633 (E2(55)= glutamine), yet TE is considerably more neurovirulent than 633. TE replicates better than 633 in a neuroblastoma cell line (N18), but similarly in BHK cells....

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Identifiers

PMID: 12021363
DOI: 10.1128/jvi.76.12.6302-631-.2002
PMCID: PMC136218

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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