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Article

Breast cancer risk associated with genotypic polymorphism of the mitotic checkpoint genes: a multigenic study on cancer susceptibility.

Carcinogenesis - 1 May 2007

Lo Yen-Li, Yu Jyh-Cherng, Chen Shou-Tung, Hsu Giu-Cheng, Mau Yi-Chien, Yang Show-Lin, Wu Pei-Ei, Shen Chen-Yang

Abstract excerpt

Aneuploidy occurs early during tumorigenesis and may contribute to tumor formation. Tumor cells become aneuploid as a result of aberrant mitotic divisions, suggesting a tumorigenic contribution of the mechanisms in maintaining chromosomal number stability. We therefore speculated that the genes TTK, MAD2L1, BUB1, BUB1B and PTTG1 (Securin), jointly implicated in the regulation of mitotic checkpoint, might be...

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Source

Identifiers

PMID: 17210994
DOI: 10.1093/carcin/bgl256

Genes

PTTG1
TTK
BUB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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