Article
Modeling the aneuploidy control of cancer.
BMC cancer - 1 Jul 2010
Li Yao, Berg Arthur, Wu Louie R, Wang Zhong, Chen Gang, Wu Rongling
Abstract excerpt
BACKGROUND: Aneuploidy has long been recognized to be associated with cancer. A growing body of evidence suggests that tumorigenesis, the formation of new tumors, can be attributed to some extent to errors occurring at the mitotic checkpoint, a major cell cycle control mechanism that acts to prevent chromosome missegregation. However, so far no statistical model has been available quantify the role aneuploidy...
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