Article
The MAD1 1673 G → A polymorphism alters the function of the mitotic spindle assembly checkpoint and is associated with a worse response to induction chemotherapy and sensitivity to treatment in patients with advanced epithelial ovarian cancer.
Pharmacogenetics and genomics - 1 Apr 2013
Santibáñez Miguel, Gallardo Dolores, Morales Flavia, López Alejandro, Prada Diddier, Mendoza Julia, Castro Clementina, de León David Cantú, Oñate Luis F, Perez Delia, Mohar Alejandro, Herrera Luis A
Abstract excerpt
BACKGROUND: Mitotic arrest deficient 1 (MAD1), a protein of the mitotic spindle assembly checkpoint (SAC), recognizes MAD2 through two leucine zippers, transporting and activating MAD2, which promotes a metaphase arrest signal. A single nucleotide polymorphism of MAD1 was found to affect the SAC function that could be involved in a poor response to therapeutic agents that alter the dynamics of microtubules....
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