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Article

Evaluation of associations between common variation in mitotic regulatory pathways and risk of overall and high grade breast cancer.

Breast cancer research and treatment - 1 Sept 2011

Stevens Kristen N, Wang Xianshu, Fredericksen Zachary, Pankratz V Shane, Cerhan James, Vachon Celine M, Olson Janet E, Couch Fergus J

Abstract excerpt

Mitotic regulatory pathways insure proper timing of mitotic entry, sister chromatid cohesion and separation, and cytokinesis. Disruption of this process results in inappropriate chromosome segregation and aneuploidy, and appears to contribute to cancer. Specifically, disregulation and somatic mutation of mitotic regulators has been observed in human cancers, and overexpression of mitotic regulators is common in...

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Identifiers

PMID: 21607584
DOI: 10.1007/s10549-011-1587-y
PMCID: PMC3508696

Genes

CDC27
CDC6
RAD21
RASSF1
SUMO3
TLK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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