Article
Genetic variation in the major mitotic checkpoint genes does not affect familial breast cancer risk.
Breast cancer research and treatment - 1 Dec 2007
Vaclavicek Annika, Bermejo Justo Lorenzo, Wappenschmidt Barbara, Meindl Alfons, Sutter Christian, Schmutzler Rita K, Kiechle Marion, Bugert Peter, Burwinkel Barbara, Bartram Claus R, Hemminki Kari, Försti Asta
Abstract excerpt
Aneuploidy, an aberrant number of chromosomes, is a very common characteristic of many types of cancers, including tumors of the breast. There is increasing evidence that defects in the spindle assembly checkpoint, which controls correct chromosome segregation between two daughter cells, might contribute to tumorigenesis. In the present study we examined the effect of promoter and coding single nucleotide...
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