Article
Genetic Variation and Recurrent Haplotypes on Chromosome 6q23-25 Risk Locus in Familial Lung Cancer.
Cancer research - 15 Jun 2021
Musolf Anthony M, Simpson Claire L, Moiz Bilal A, Pikielny Claudio W, Middlebrooks Candace D, Mandal Diptasri, de Andrade Mariza, Cole Michael D, Gaba Colette, Yang Ping, You Ming, Li Yafang, Kupert Elena Y, Anderson Marshall W, Schwartz Ann G, Pinney Susan M, Amos Christopher I, Bailey-Wilson Joan E
Abstract excerpt
Although lung cancer is known to be caused by environmental factors, it has also been shown to have genetic components, and the genetic etiology of lung cancer remains understudied. We previously identified a lung cancer risk locus on 6q23-25 using microsatellite data in families with a history of lung cancer. To further elucidate that signal, we performed targeted sequencing on nine of our most strongly linked...
Topics
- Biomarkers, Tumor
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Female
- Genetic Linkage
- Genetic Predisposition to Disease
- Genetic Variation
- Genome, Human
- Haplotypes