Article
Fine mapping of chromosome 6q23-25 region in familial lung cancer families reveals RGS17 as a likely candidate gene.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2009
You Ming, Wang Daolong, Liu Pengyuan, Vikis Haris, James Michael, Lu Yan, Wang Yian, Wang Min, Chen Qiong, Jia Dongmei, Liu Yan, Wen Weidong, Yang Ping, Sun Zhifu, Pinney Susan M, Zheng Wei, Shu Xiao-Ou, Long Jirong, Gao Yu-Tang, Xiang Yong-Bing, Chow Wong-Ho, Rothman Nat, Petersen Gloria M, de Andrade Mariza, Wu Yanhong, Cunningham Julie M, Wiest Jonathan S, Fain Pamela R, Schwartz Ann G, Girard Luc, Gazdar Adi, Gaba Colette, Rothschild Henry, Mandal Diptasri, Coons Teresa, Lee Juwon, Kupert Elena, Seminara Daniela, Minna John, Bailey-Wilson Joan E, Amos Christopher I, Anderson Marshall W
Abstract excerpt
PURPOSE: We have previously mapped a major susceptibility locus influencing familial lung cancer risk to chromosome 6q23-25. However, the causal gene at this locus remains undetermined. In this study, we further refined this locus to identify a single candidate gene, by fine mapping using microsatellite markers and association studies using high-density single nucleotide polymorphisms (SNP). EXPERIMENTAL DESIGN:...
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