Article
Analysis of a 69-kb contiguous genomic sequence at a putative tumor suppressor gene locus on human chromosome 6q27.
DNA sequence : the journal of DNA sequencing and mapping - 1 Jan 1998
Qu X Y, Hauptschein R S, Rzhetsky A, Scotto L, Chien M C, Ye X, Frigeri F, Rao P H, Pasqualucci L, Gamberi B, Deaven L L, Zhang P, Chaganti R S, Dalla-Favera R, Russo J J
Abstract excerpt
Multiple neoplasias including B-cell non-Hodgkin's lymphoma, breast carcinoma, and ovarian carcinoma, have been associated with frequent deletions of the distal region on the long arm of human chromosome 6, suggesting the presence of one or more tumor suppressor gene(s) at this locus. Loss of heterozygosity analysis of breast and ovarian tumors has further restricted the minimal region of loss within 6q27. To...
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