Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation.

Biochemical and biophysical research communications - 2 Mar 2007

Suganami Takayoshi, Mieda Tae, Itoh Michiko, Shimoda Yuri, Kamei Yasutomi, Ogawa Yoshihiro

Abstract excerpt

Obese adipose tissue is characterized by increased infiltration of macrophages, suggesting that they might represent an important source of inflammation. We have provided in vitro evidence that saturated fatty acids, which are released from hypertrophied adipocytes via the macrophage-induced adipocyte lipolysis, serve as a naturally occurring ligand for Toll-like receptor 4 (TLR4) to induce the inflammatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cells, Cultured

Share to Mice, Inbred C3H

Share to Obesity

Share to Panniculitis

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 17210129
DOI: 10.1016/j.bbrc.2006.12.190

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation.PMID 17210129Read ↗

C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet.Semantic proximity Read ↗

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.Semantic proximity Read ↗

Adipose tissue macrophages: their role in adipose tissue remodeling.Semantic proximity Read ↗

Obesity activates toll-like receptor-mediated proinflammatory signaling cascades in the adipose tissue of mice.Semantic proximity Read ↗

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity.Semantic proximity Read ↗

Opposing Actions of TLR2 and TLR4 in Adipocyte Differentiation and Mature-Onset ObesitySemantic proximity Read ↗

<i>Tlr2</i> is critical for diet‐induced metabolic syndrome in a murine modelSemantic proximity Read ↗

A role for TLR10 in obesity and adipose tissue morphology.Semantic proximity Read ↗

Free fatty acid receptor 4 is a nutrient sensor that resolves inflammation to maintain cardiac homeostasisSemantic proximity Read ↗

Ablation of toll-like receptor 4 mitigates cardiac mitochondrial dysfunction in hyperhomocysteinemia.Semantic proximity Read ↗

Obesity-associated improvements in metabolic profile through expansion of adipose tissue.Semantic proximity Read ↗

Genetic Deletion of Syndecan-4 Alters Body Composition, Metabolic Phenotypes, and the Function of Metabolic Tissues in Female Mice Fed A High-Fat Diet.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.