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Article

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.

Diabetes - 1 Aug 2007

Tsukumo Daniela M L, Carvalho-Filho Marco A, Carvalheira José B C, Prada Patrícia O, Hirabara Sandro M, Schenka André A, Araújo Eliana P, Vassallo José, Curi Rui, Velloso Lício A, Saad Mario J A

Abstract excerpt

Obesity is associated with insulin resistance and a state of abnormal inflammatory response. The Toll-like receptor (TLR)4 has an important role in inflammation and immunity, and its expression has been reported in most tissues of the body, including the insulin-sensitive ones. Because it is activated by lipopolysaccharide and saturated fatty acids, which are inducers of insulin resistance, TLR4 may be a...

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PMID: 17519423
DOI: 10.2337/db06-1595

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TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance.PMID 17519423Read ↗

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