Article
A role for TLR10 in obesity and adipose tissue morphology.
Cytokine - 1 Aug 2018
Boutens Lily, Mirea Andreea-Manuela, van den Munckhof Inge, Doppenberg-Oosting Marije, Jaeger Martin, Hijmans Anneke, Netea Mihai G, Joosten Leo A B, Stienstra Rinke
Abstract excerpt
Toll like receptors (TLRs) are expressed in adipose tissue and promote adipose tissue inflammation during obesity. Recently, anti-inflammatory properties have been attributed to TLR10 in myeloid cells, the only member of the TLR family with inhibitory activity. In order to assess whether TLR10-induced inhibition of inflammation may be protective during the development of obesity and metabolic abnormalities we...
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