Article
Genetic Deletion of Syndecan-4 Alters Body Composition, Metabolic Phenotypes, and the Function of Metabolic Tissues in Female Mice Fed A High-Fat Diet.
Nutrients - 18 Nov 2019
De Luca Maria, Vecchie' Denise, Athmanathan Baskaran, Gopalkrishna Sreejit, Valcin Jennifer A, Swain Telisha M, Sertie Rogerio, Wekesa Kennedy, Rowe Glenn C, Bailey Shannon M, Nagareddy Prabhakara R
Abstract excerpt
Syndecans are transmembrane proteoglycans that, like integrins, bind to components of the extracellular matrix. Previously, we showed significant associations of genetic variants in the Syndecan-4 (SDC4) gene with intra-abdominal fat, fasting plasma glucose levels, and insulin sensitivity index in children, and with fasting serum triglyceride levels in healthy elderly subjects. An independent study also reported...
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