Article
Haptoglobin genotype determines myocardial infarct size in diabetic mice.
Journal of the American College of Cardiology - 2 Jan 2007
Blum Shany, Asaf Roy, Guetta Julia, Miller-Lotan Rachel, Asleh Rabea, Kremer Ran, Levy Nina S, Berger Franklin G, Aronson Doron, Fu Xiaoming, Zhang Renliang, Hazen Stanley L, Levy Andrew P
Abstract excerpt
OBJECTIVES: We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM). BACKGROUND: Two common alleles (1 and 2) exist at the Hp locus in humans. The Hp 2 allele is associated with increased MI size in individuals with DM. In vitro, the Hp 2 protein is associated with increased generation of...
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