Article
Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2012
Purushothaman Meerarani, Krishnan Prakash, Purushothaman K-Raman, Baber Usman, Tarricone Arthur, Perez Juan S, Wiley Jose, Kini Annapoorna, Sharma Samin K, Fuster Valentin, Moreno Pedro R
Abstract excerpt
OBJECTIVE: Haptoglobin (Hp) protein is responsible for hemoglobin clearance after intra-plaque hemorrhage. Hp gene exists as Hp-1 and Hp-2 alleles and the phenotypes show important molecular heterogeneity. We tested the hypothesis that hemoglobin clearance may be deficient in diabetic atheroma from patients with Hp2-2, triggering increased oxidative, inflammatory, and angiogenic patterns compared with controls....
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