Article
Vitamin E supplementation reduces cardiovascular events in a subgroup of middle-aged individuals with both type 2 diabetes mellitus and the haptoglobin 2-2 genotype: a prospective double-blinded clinical trial.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2008
Milman Uzi, Blum Shany, Shapira Chen, Aronson Doron, Miller-Lotan Rachel, Anbinder Yefim, Alshiek Junia, Bennett Lawrence, Kostenko Maria, Landau Michele, Keidar Shlomo, Levy Yishai, Khemlin Alexander, Radan Arman, Levy Andrew P
Abstract excerpt
OBJECTIVE: Clinical trials of vitamin E have failed to demonstrate a decrease in cardiovascular events. However, these studies did not address possible benefit to subgroups with increased oxidative stress. Haptoglobin (Hp), a major antioxidant protein, is a determinant of cardiovascular events in patients with Type 2 diabetes mellitus (DM). The Hp gene is polymorphic with 2 common alleles, 1 and 2. The Hp 2...
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