Article
Downregulation of the hemoglobin scavenger receptor in individuals with diabetes and the Hp 2-2 genotype: implications for the response to intraplaque hemorrhage and plaque vulnerability.
Circulation research - 6 Jul 2007
Levy Andrew P, Purushothaman K Raman, Levy Nina S, Purushothaman Meerarani, Strauss Merav, Asleh Rabea, Marsh Stuart, Cohen Osher, Moestrup Soren K, Moller Holger J, Zias Elias A, Benhayon Daniel, Fuster Valentin, Moreno Pedro R
Abstract excerpt
In individuals with diabetes mellitus (DM), the haptoglobin (Hp) genotype is a major determinant of susceptibility to myocardial infarction. We have proposed that this is because of DM and Hp genotype-dependent differences in the response to intraplaque hemorrhage. The macrophage hemoglobin scavenging receptor CD163 plays an essential role in the clearance of hemoglobin released from lysed red blood cells after...
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