Article
Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo.
Circulation research - 8 Dec 2006
Asleh Rabea, Miller-Lotan Rachael, Aviram Michael, Hayek Tony, Yulish Michael, Levy Joanne E, Miller Benjamin, Blum Shany, Milman Uzi, Shapira Chen, Levy Andrew P
Abstract excerpt
Two common alleles exist at the haptoglobin (Hp) locus, and the Hp2 allele is associated with an increased incidence of cardiovascular disease, specifically in diabetes mellitus (DM). Oxidative stress is increased in Hp2 mice and humans with DM. Oxidative modification of the apolipoprotein A-I inhibits reverse cholesterol transport. We sought to test the hypothesis that reverse cholesterol transport is impaired...
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