Article
Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2007
Levy Andrew P, Levy Joanne E, Kalet-Litman Shiri, Miller-Lotan Rachel, Levy Nina S, Asaf Roy, Guetta Julia, Yang Chingwen, Purushothaman K Raman, Fuster Valentin, Moreno Pedro R
Abstract excerpt
OBJECTIVE: Intraplaque hemorrhage increases the risk of plaque rupture and thrombosis. The release of hemoglobin (Hb) from extravasated erythrocytes at the site of hemorrhage leads to iron deposition, which may increase oxidation and inflammation in the atherosclerotic plaque. The haptoglobin (Hp) protein is critical for protection against Hb-induced injury. Two common alleles exist at the Hp locus and the Hp 2...
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