Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo.

Circulation research - 4 Mar 2005

Asleh Rabea, Guetta Julia, Kalet-Litman Shiri, Miller-Lotan Rachel, Levy Andrew P

Abstract excerpt

We have recently demonstrated in multiple independent population-based longitudinal and cross sectional analyses that the haptoglobin 2-2 genotype is associated with an increased risk for diabetic cardiovascular disease. The chief function of haptoglobin (Hp) is to bind to hemoglobin and thereby prevent hemoglobin-induced oxidative tissue damage. This antioxidant function of haptoglobin is mediated in part by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deferoxamine
Share to Diabetes Mellitus, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluoresceins

Share to Glycated Hemoglobin

Share to Haptoglobins

Share to Hemoglobins

Share to Iron Chelating Agents

Share to Lipid Peroxidation

Source

Identifiers

PMID: 15662028
DOI: 10.1161/01.RES.0000156653.05853.b9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo.PMID 15662028Read ↗

Haptoglobin genotype and its role in determining heme-iron mediated vascular disease.Semantic proximity Read ↗

Divergent effects of alpha-tocopherol and vitamin C on the generation of dysfunctional HDL associated with diabetes and the Hp 2-2 genotype.Semantic proximity Read ↗

Haptoglobin: basic and clinical aspects.Semantic proximity Read ↗

Is it time to screen for the haptoglobin genotype to assess the cardiovascular risk profile and vitamin E therapy responsiveness in patients with diabetes?Semantic proximity Read ↗

Haptoglobin genotype is a regulator of reverse cholesterol transport in diabetes in vitro and in vivo.Semantic proximity Read ↗

Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype.Semantic proximity Read ↗

Haptoglobin genotype determines myocardial infarct size in diabetic mice.Semantic proximity Read ↗

Hypothesis--haptoglobin genotype and diabetic nephropathy.Semantic proximity Read ↗

In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease.Semantic proximity Read ↗

Vitamin E therapy results in a reduction in HDL function in individuals with diabetes and the haptoglobin 2-1 genotype.Semantic proximity Read ↗

Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease.Semantic proximity Read ↗

Application of pharmacogenomics in the prevention of diabetic cardiovascular disease: mechanistic basis and clinical evidence for utilization of the haptoglobin genotype in determining benefit from antioxidant therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.