A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs.

doi:10.1016/j.humimm.2006.09.004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs.

Human immunology - 1 Jan 2007

Hurley Carolyn Katovich, Fernandez-Vina Marcelo, Hildebrand William H, Noreen Harriet J, Trachtenberg Elizabeth, Williams Thomas M, Baxter-Lowe Lee Ann, Begovich Ann B, Petersdorf Effie, Selvakumar Annamalai, Stastny Peter, Hegland Janet, Hartzman Robert J, Carston Michael, Gandham Sharavi, Kollman Craig, Nelson Gene, Spellman Stephen, Setterholm Michelle

Abstract excerpt

The allelic diversity and associated human leukocyte antigen (HLA) disparity of 1775 bone marrow recipients and their unrelated donors, matched for six of six (1361/1775,77%), five of six (397/1775, 22%), or four of six (17/1775, 1%) HLA-A, -B, -DR antigens, were retrospectively evaluated. The comprehensive HLA analysis included the class I (A, B, C) and II (DRB1, DQA1, DQB1, DPA1, DPB1) loci. Most (>66%) of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bone Marrow Transplantation

Share to Genetic Variation

Share to Histocompatibility Antigens Class I

Share to Histocompatibility Testing

Share to HLA Antigens

Share to HLA-D Antigens

Share to Tissue Donors

Source

Open in PubMed

Identifiers

PMID: 17207710
DOI: 10.1016/j.humimm.2006.09.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A high degree of HLA disparity arises from limited allelic diversity: analysis of 1775 unrelated bone marrow transplant donor-recipient pairs.PMID 17207710Read ↗

The extent of HLA class II allele level disparity in unrelated bone marrow transplantation: analysis of 1259 National Marrow Donor Program donor-recipient pairs.Semantic proximity Read ↗

HLA-A Disparities Illustrate Challenges for Ranking the Impact of HLA Mismatches on Bone Marrow Transplant Outcomes in the United StatesSemantic proximity Read ↗

Role of major histocompatibility complex variation in graft-versus-host disease after hematopoietic cell transplantationSemantic proximity Read ↗

Landscapes of HLA Mismatching in Contemporary Unrelated Haematopoietic Cell Transplantation.Semantic proximity Read ↗

High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation.Semantic proximity Read ↗

Molecular disparity in human leukocyte antigens is associated with outcomes in haploidentical stem cell transplantationSemantic proximity Read ↗

Impact of HLA allele mismatch at HLA-A, -B, -C, -DRB1, and -DQB1 on outcomes in haploidentical stem cell transplantation.Semantic proximity Read ↗

The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors.Semantic proximity Read ↗

Evaluation of HLA matching in unrelated hematopoietic stem cell transplantation for nonmalignant disordersSemantic proximity Read ↗

Interindividual HLA Evolutionary Divergence in Single HLA-Mismatched Unrelated Donor Hematopoietic Cell Transplantation for Malignant Hematological Disorders: A Report on Behalf of the Cellular Therapy and Immunobiology Working Party of the EBMTSemantic proximity Read ↗

Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research.Semantic proximity Read ↗

HLA-inferred extended haplotype disparity level is more relevant than the level of HLA mismatch alone for the patients survival and GvHD in T cell-replate hematopoietic stem cell transplantation from unrelated donor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.