Article
The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors.
Blood - 1 Jun 2002
Morishima Yasuo, Sasazuki Takehiko, Inoko Hidetoshi, Juji Takeo, Akaza Tatsuya, Yamamoto Ken, Ishikawa Yoshihide, Kato Shunichi, Sao Hiroshi, Sakamaki Hisashi, Kawa Keisei, Hamajima Nobuyuki, Asano Shigetaka, Kodera Yoshihisa
Abstract excerpt
To improve the clinical outcome of allogeneic hematopoietic stem cell transplantation from an unrelated donor, the identification of human leukocyte antigen (HLA) alleles responsible for immunologic events such as graft-versus-host disease (GVHD), engraftment failure, and graft-versus-leukemia effect is essential. Genomic typing of HLA-A, -B, -C, -DRB1, and -DQB1 was retrospectively performed in 1298...
Topics
- Adult
- Alleles
- Anemia, Aplastic
- Bone Marrow Transplantation
- Female
- Genetic Diseases, Inborn
- Graft vs Host Disease
- Graft vs Leukemia Effect
- HLA-A Antigens