Article
HLA-inferred extended haplotype disparity level is more relevant than the level of HLA mismatch alone for the patients survival and GvHD in T cell-replate hematopoietic stem cell transplantation from unrelated donor.
Human immunology - 1 Jun 2018
Nowak Jacek, Nestorowicz Klaudia, Graczyk-Pol Elzbieta, Mika-Witkowska Renata, Rogatko-Koros Marta, Jaskula Emilia, Koscinska Katarzyna, Madej Sylwia, Tomaszewska Agnieszka, Nasilowska-Adamska Barbara, Szczepinski Andrzej, Halaburda Kazimierz, Dybko Jaroslaw, Kuliczkowski Kazimierz, Czerw Tomasz, Giebel Sebastian, Holowiecki Jerzy, Baranska Malgorzata, Pieczonka Anna, Wachowiak Jacek, Czyz Anna, Gil Lidia, Lojko-Dankowska Anna, Komarnicki Mieczyslaw, Bieniaszewska Maria, Kucharska Agnieszka, Hellmann Andrzej, Gronkowska Anna, Jedrzejczak Wieslaw W, Markiewicz Miroslaw, Koclega Anna, Kyrcz-Krzemien Slawomira, Mielcarek Monika, Kalwak Krzysztof, Styczynski Jan, Wysocki Mariusz, Drabko Katarzyna, Wojcik Beata, Kowalczyk Jerzy, Gozdzik Jolanta, Pawliczak Daria, Gwozdowicz Slawomir, Dziopa Joanna, Szlendak Urszula, Witkowska Agnieszka, Zubala Marta, Gawron Agnieszka, Warzocha Krzysztof, Lange Andrzej
Abstract excerpt
Serious risks in unrelated hematopoietic stem cell transplantation (HSCT) including graft versus host disease (GvHD) and mortality are associated with HLA disparity between donor and recipient. The increased risks might be dependent on disparity in not-routinely-tested multiple polymorphisms in genetically dense MHC region, being organized in combinations of two extended MHC haplotypes (Ehp). We assessed the...
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