Article
Human leukocyte antigen supertype matching after myeloablative hematopoietic cell transplantation with 7/8 matched unrelated donor allografts: a report from the Center for International Blood and Marrow Transplant Research.
Haematologica - 1 Oct 2016
Lazaryan Aleksandr, Wang Tao, Spellman Stephen R, Wang Hai-Lin, Pidala Joseph, Nishihori Taiga, Askar Medhat, Olsson Richard, Oudshoorn Machteld, Abdel-Azim Hisham, Yong Agnes, Gandhi Manish, Dandoy Christopher, Savani Bipin, Hale Gregory, Page Kristin, Bitan Menachem, Reshef Ran, Drobyski William, Marsh Steven Ge, Schultz Kirk, Müller Carlheinz R, Fernandez-Viña Marcelo A, Verneris Michael R, Horowitz Mary M, Arora Mukta, Weisdorf Daniel J, Lee Stephanie J
Abstract excerpt
The diversity of the human leukocyte antigen (HLA) class I and II alleles can be simplified by consolidating them into fewer supertypes based on functional or predicted structural similarities in epitope-binding grooves of HLA molecules. We studied the impact of matched and mismatched HLA-A (265 versus 429), -B (230 versus 92), -C (365 versus 349), and -DRB1 (153 versus 51) supertypes on clinical outcomes of 1934...
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