Evaluation of HLA matching in unrelated hematopoietic stem cell transplantation for nonmalignant disorders

doi:10.1182/blood-2012-03-417758

Article

Evaluation of HLA matching in unrelated hematopoietic stem cell transplantation for nonmalignant disorders

25 Jul 2012

Abstract excerpt

The importance of human leukocyte antigen (HLA) matching in unrelated donor transplantation for nonmalignant diseases (NMD) has yet to be defined. We analyzed data from 663 unrelated marrow and peripheral blood stem cell transplants performed from 1995 to 2007 for treatment of NMD. Transplantation from a donor mismatched at the HLA-A, -B, -C, or -DRB1, but not -DQB1 or -DPB1, loci was associated with higher...

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