Article
The extent of HLA class II allele level disparity in unrelated bone marrow transplantation: analysis of 1259 National Marrow Donor Program donor-recipient pairs.
Bone marrow transplantation - 1 Feb 2000
Hurley C K, Baxter-Lowe L A, Begovich A B, Fernandez-Vina M, Noreen H, Schmeckpeper B, Awdeh Z, Chopek M, Salazar M, Williams T M, Yunis E J, Kitajima D, Shipp K, Splett J, Winden T, Kollman C, Johnson D, Ng J, Hartzman R J, Hegland J
Abstract excerpt
A comprehensive analysis of the HLA-D region loci, DRB1, DRB3, DRB5, DQA1, DQB1, DPA1 and DPB1, was performed to determine allelic diversity and underlying HLA disparity in 1259 bone marrow recipients and their unrelated donors transplanted through the National Marrow Donor Program. Although 43.0% of DRB1 alleles known to exist at the beginning of the study were found in this predominantly Caucasian transplant...
Topics
- Alleles
- Bone Marrow Transplantation
- Genetic Variation
- Histocompatibility Antigens Class II
- Histocompatibility Testing
- Humans
- Polymorphism, Genetic
- Transplantation Immunology