Article
A high-resolution map of segmental DNA copy number variation in the mouse genome.
PLoS genetics - 5 Jan 2007
Graubert Timothy A, Cahan Patrick, Edwin Deepa, Selzer Rebecca R, Richmond Todd A, Eis Peggy S, Shannon William D, Li Xia, McLeod Howard L, Cheverud James M, Ley Timothy J
Abstract excerpt
Submicroscopic (less than 2 Mb) segmental DNA copy number changes are a recently recognized source of genetic variability between individuals. The biological consequences of copy number variants (CNVs) are largely undefined. In some cases, CNVs that cause gene dosage effects have been implicated in phenotypic variation. CNVs have been detected in diverse species, including mice and humans. Published studies in...
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