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Article

Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress.

Oncogene - 9 Feb 2006

Speidel D, Helmbold H, Deppert W

Abstract excerpt

Following genotoxic stress, p53 either rescues a damaged cell or promotes its elimination. The parameters determining a specific outcome of the p53 response are largely unknown. In mouse fibroblasts treated with different irradiation schemes, we monitored transcriptional and non-transcriptional p53 activities and identified determinants that initiate an anti- or a pro-apoptotic p53 response within the context of...

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PMID: 16247471
DOI: 10.1038/sj.onc.1209126

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Dissection of transcriptional and non-transcriptional p53 activities in the response to genotoxic stress.PMID 16247471Read ↗

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