Article
Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation.
Oncogene - 3 Dec 1998
Hengstermann A, Whitaker N J, Zimmer D, Zentgraf H, Scheffner M
Abstract excerpt
The growth suppressive properties of the tumor suppressor protein p53 are activated upon DNA damage. The activation of p53 is reflected in increased p53 levels which are, at least in part, the result of an extended half-life of the protein. Although this suggests that stabilization of p53 is an intrinsic feature of p53 activation, the mechanisms involved in p53 degradation and stabilization are poorly understood....
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