Article
Effect of p53 genotype on gene expression profiles in murine liver.
Mutation research - 2 Apr 2008
Morris Suzanne M, Akerman Gregory S, Desai Varsha G, Tsai Chen-An, Tolleson William H, Melchior William B, Lin Chien-Ju, Fuscoe James C, Casciano Daniel A, Chen James J
Abstract excerpt
The tumor suppressor protein p53 is a key regulatory element in the cell and is regarded as the "guardian of the genome". Much of the present knowledge of p53 function has come from studies of transgenic mice in which the p53 gene has undergone a targeted deletion. In order to provide additional insight into the impact on the cellular regulatory networks associated with the loss of this gene, microarray...
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