Article
Persistence of HIV-1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy can be explained by compensatory fixation.
The Journal of infectious diseases - 1 Feb 2007
van Maarseveen Noortje M, Wensing Annemarie M J, de Jong Dorien, Taconis Maaike, Borleffs Jan C C, Boucher Charles A B, Nijhuis Monique
Abstract excerpt
OBJECTIVE: To investigate the mechanism explaining the persistence of human immunodeficiency virus (HIV) type 1 variants with multiple protease inhibitor (PI)-resistance mutations in the absence of PI therapy. METHODS: Longitudinal genotypic analyses were performed on sequential samples obtained from 2 HIV-1-infected patients who had stopped PI therapy for 4 years. Replication capacity (RC) was determined using...
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